Activation of skeletal muscle–resident glial cells upon nerve injury
نویسندگان
چکیده
منابع مشابه
p10: reactive glial cells for brain injury
a common pathological process that occurred after brain injury is gliosis. gliosis involves the activation of glial cells to proliferate and become hypertrophic to occupy the injured brain areas. in order to form a defense system against the invasion of micro-organisms and cytotoxins into surrounding tissue, glial cells including astrocytes and microglia undergo reactive response to injury. neu...
متن کاملiTRAQ-based proteomics profiling of Schwann cells before and after peripheral nerve injury
Objective(s): Schwann cells (SCs) have a wide range of applications as seed cells in the treatment of nerve injury during transplantation. However, there has been no report yet on kinds of proteomics changes that occur in Schwann cells before and after peripheral nerve injury.Materials and Methods: Activated Schwann cells (ASCs) and normal Schwann cells (NSCs) were obtained from adult Wistar ra...
متن کاملAbstract P27: Macrophage Recruitment and Activation to Skeletal Muscle after Acute Nerve Injury
PURPOSE: Regenerative Peripheral Nerve Interfaces (RPNIs) can be used to treat symptomatic end neuromas that develop after major limb amputation. Symptomatic neuromas occur in approximately 30–40% of individuals after limb loss and phantom limb pain affects 70–95% of these patients. We investigate the potential of prophylactic RPNIs to prevent neuroma formation and to mitigate the experience of...
متن کاملBridging long gap peripheral nerve injury using skeletal muscle-derived multipotent stem cells
Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells (Sk-MSCs) can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerv...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2021
ISSN: 2379-3708
DOI: 10.1172/jci.insight.143469